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KMID : 0043320180410070725
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Archives of Pharmacal Research
2018 Volume.41 No. 7 p.725 ~ p.736
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Drug-induced hyperglycaemia and diabetes: pharmacogenomics perspectives
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Liu Mou-Ze
He Hai-Yan
Luo Jian-Quan
He Fa-Zhong
Chen Zhang-Ren
Liu Yi-Ping
Xiang Da-Xiong
Zhou Hong-Hao
Zhang Wei
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Abstract
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Drug-induced diabetes is widely reported in clinical conditions, and it is becoming a global issue because of its potential to increase the risk of severe cardiovascular complications. However, which drug mechanisms exert their diabetogenic effects and why the effects present significant inter-individual differences remain largely unknown. Pharmacogenomics, which is the study of how genomic variation influences drug responses, provides an explanation for individual differences in drug-induced diabetes. We highlight that pharmacogenomics can be involved in regulating the expression of genes in signaling pathways related to the pharmacokinetics or pharmacodynamics of drugs or the pathogenesis of diabetes, contributing to the differences in drug-induced glucose impairment. The pharmacogenomics studies of the major diabetogenic drugs are reviewed, including calcineurin inhibitors, antipsychotics, hormones, and antihypertensive drugs. We intend to elucidate the genetic basis of drug-induced diabetes and pave the way for the precise use of these drugs in the clinic.
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KEYWORD
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Drug-induced diabetes, Pharmacogenomics, Hyperglycemia, Calcineurin inhibitors, Antipsychotic, Antihypertensive, Precision medicine
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